CD33 and acute myeloid leukemia: One research group proposed a novel solution to this problem by removing CD33 from normal hematopoietic stem progenitor cells (HSPCs) using genomic editing during CD33-mediated CAR T cell treatment of AML, as CD33 is not essential to hematopoietic differentiation, and a lack of CD33 in myeloid progeny does not cause any visible functional changes [72].