Subsequently, one group generated a novel anti-CD123-CD28-CD137-CD27-CD3ζ-iCasp9 CAR (4SCAR123) that exhibited potent cytotoxicity against AML in vitro and then infused 4SCAR123 into a 47-year-old male patient with AML-M2. The gene discussed is CD28; the disease is acute myeloid leukemia.