The most common and harmful toxicity is cytokine release syndrome (CRS), a rapid and evident inflammatory systemic response caused by dramatic increases in many inflammatory cytokines (e.g., soluble IL-2R, IL-6 levels, ferritin, C-reactive protein (CRP), etc.)that occur with the in vivo activation and exponential proliferation of CAR T cells. This evidence concerns the gene CRP and congenital rubella syndrome.