Using Kaplan-Meier survival analysis, we found that these five groups were well segregated (P = 0.000) (Fig. 4a) and patients with IDH-mutant gliomas had significantly better survival compared to those with IDH-WT gliomas (P < 0.001, P < 0.003) (Fig. 4b and c). Here, IDH2 is linked to central nervous system cancer.