IDH2 and astrocytic tumor: In addition, we found that the MGMTp methylation group had better survival in combined grade III and IV astrocytic tumors and in both IDH-mutant and IDH-WT GBMs; however, we found that ATRX mutation did not confer a prognostic effect in any of the five groups evaluated in our study, which is different from Pekmezci et al.’s conclusion [23].