MRIs, X-rays, CTs, C-reactive protein (CRP), and digital infrared thermal imaging (DITI) were most frequently referred to for LSS diagnosis, and MRIs were reported to be used 98.4%, X-rays 94.3%, CTs 66.7%, CRP 9.8%, and DITIs 6.5%, revealing a strong preference for radiological findings. The gene discussed is CRP; the disease is Leigh syndrome.