IL6 and breast cancer: In multivariate analysis, the association between an IL-6 and D-dimer level in the highest (4th) quartile and an RDI < 85% remained significant (OR 2.54, 95% CI 1.03–6.23; p = 0.04) after adjusting for patient age, physical function (ADL score), breast cancer stage, and receipt of an anthracycline regimen (Table 7).