BACE1 and Cognitive impairment: If miR-574-5p directly binds to the 3’UTR of BACE1 and miR-574-5p deregulation stimulates BACE1 expression and impairs synaptic and cognitive function in response to PM2.5 aspiration, then overexpression of miR-574-5p should suppress BACE1 elevation and restore synaptic and cognitive impairment.