We previously reported that cultured DF cells obtained from a patient with S45F mutation showed strong nuclear expression of β-catenin immunohistochemically and higher mRNA expression levels of Wnt target genes, Axin-2 and Cyclin-D1, with RT-PCR compared with DF cells from patients without S45F mutation (T41A and wild type) [29]. The gene discussed is AXIN2; the disease is dengue disease.