On one hand, TIPE2 expression is down-regulated in peripheral blood mononuclear cells (PBMCs) of patients with SLE [11] and HBV [9] or HCV-induced hepatitis [12], as well as gastric cancer [13], hepatocellular carcinoma [14] and non-small cell lung cancer tissues [15]. This evidence concerns the gene TIPE2 and hepatocellular carcinoma.