TIPE2 and hereditary clear cell renal cell carcinoma: On the other hand, it has been reported that TIPE2 expression is up-regulated in glomeruli from streptozotocin (STZ)-induced diabetic rats and renal biopsies of patients with diabetes [8], and PBMCs of chronic rejection patients [28], as well as renal cell carcinoma tissues [29], Non-Hodgkin’s Lymphoma [30].