Then they compared ser (P)-1292 LRRK2 levels in urine samples of 79 Parkinson’s disease patients with 79 healthy controls and found that ser (P)-1292 level in urinary exosomes of primary Parkinson’s disease patients was significantly increased as compared to controls, and was closely related to severity of the disease [122]. This evidence concerns the gene LRRK2 and Parkinson disease.