The comparison of exosomal proteome between KRAS wild type DKS-8 cells of human colon adenocarcinoma cells DLD-1 and K-RAS mutant type DKO-1 cells indicated that DKS-8 secreted by DKO-1 exosomes was not only significantly proliferated but its invasion capacity was also increased. This evidence concerns the gene KRAS and colon adenocarcinoma.