Interestingly, In1-ghrelin, but not native-ghrelin, levels positively correlated with GOAT-expression in PCa, an association that has also been previously found in other endocrine-related tumors [20, 22, 23], and suggests that In1-ghrelin may be the main ghrelin-gene variant functionally linked to GOAT in those tumors, which also reinforces the idea that an autocrine/paracrine-circuit involving these two components of the ghrelin-system may operate in PCa. This evidence concerns the gene GHRL and posterior cortical atrophy.