Our study demonstrates that native-ghrelin can also display significant effects on the functional endpoints measured (in vitro proliferation and/or migration and in vivo proliferation and inflammation), although they are more reduced compared to In1-ghrelin effects, suggesting that native-ghrelin could be playing a role on other endpoints not measured herein, and that In1-ghrelin spliced variant has a more relevant role than native-ghrelin in the aggressiveness of PCa cells. The gene discussed is GHRL; the disease is posterior cortical atrophy.