Interestingly, some of these changes in mRNA and protein expression (Fig. 5b, c) were similar in the In1-ghrelin and native-ghrelin stably-transfected PC-3-cells (e.g. SFRP1/NRIP1 downregulation); but, most noteworthy, that some of these changes were regulated oppositely in both PCa cell-models (i.e. downregulation in native-ghrelin and up-regulation in In1-ghrelin stably-transfected PC-3-cells of LOXL1/IGFBP5; Fig. 5b, c). This evidence concerns the gene GHRL and posterior cortical atrophy.