Accordingly, it is tempting to speculate that the upregulation of LOXL1 and IGFBP5 observed in PCa-cells overexpressing In1-ghrelin might be associated to the increased aggressiveness-features observed in PCa cells (i.e. in vitro and/or in vivo cell proliferation, migration, tumor growth and PSA secretion). Here, IGFBP5 is linked to neoplasm.