Moreover, to further explore this notion, we generated, for the first time, nude mice injected with In1-ghrelin or with native-ghrelin stably-transfected PC-3 cells and found that In1-ghrelin, but not native-ghrelin, overexpression enhanced tumors-growth in this in vivo preclinical-model (i.e. larger tumors), wherein it increased tumor-necrosis, likely due to higher tumor volume supporting the idea that In1-ghrelin would increase the malignant features of PCa cells. This evidence concerns the gene GHRL and neoplasm.