Interestingly, In1-ghrelin, but not native-ghrelin overexpression clearly increased cell-viability, and In1-ghrelin treatment also increased PSA-secretion/expression in NP cell-cultures, which is consistent with data previously reported indicating that In1-ghrelin treatment enhances hormone-secretion in other cell-types [i.e. serotonin in NETs cells [23], GH in somatotropinoma cells and, ACTH in corticotropinoma cells [22]] and may suggest a relevant role of In1-ghrelin in the malignization of NP-cells. Here, GHRL is linked to growth hormone-producing pituitary gland neoplasm.