GHRL and posterior cortical atrophy: In line with this, the increase in LOXL1 and IGFBP5 expression observed in PCa cells overexpressing In1-ghrelin could be pathophysiological relevant and could be associated to the unique capacity of In1-ghrelin to enhance the malignancy-features in PCa cells, since both factors have been shown to increase the aggressiveness of PCa-cells [40–43].