Our data shed light on the currently controversial data on SFRP5 and type 2 diabetes by demonstrating that higher serum SFRP5 was significantly linked to lower odds of prediabetes/type 2 diabetes (as combined group of individuals with impaired glucose regulation) even after adjustment for age, sex, BMI, lifestyle factors and risk factors for cardiovascular diseases. This evidence concerns the gene SFRP5 and type 2 diabetes mellitus.