Importantly, the oncogenic properties of PLPP5 were further demonstrated by its ability to transform NIH-3 T3 fibroblasts, further inducing their anchorage-independent growth [6]; in oral squamous cell carcinoma (OSCC) patients, PLPP3 was downregulated in approximately 70% OSCC patients and PLPP3 expression negatively correlated with TNM stage and tumor volume [7]. Here, PLPP3 is linked to oral cavity squamous cell carcinoma.