Membranous EpCAM staining was positively correlated with nuclear β-catenin localization in our study population (correlation coefficient = 0.52; P = 0.003), and nuclear β-catenin localization was also predictive of the presence of membranous EpCAM (Odds ratio, 14.67; 95% CI: 2.07–104.86; P = 0.01) in hepatoblastoma tumor specimens. This evidence concerns the gene EPCAM and hepatoblastoma.