There are also several new poor prognostic markers in hepatoblastoma reported by Children’s Hepatic tumors International Collaboration (CHIC) in recent years, including diagnostic age (≧8 years in PRETEXT I-III, and ≧ 3 years in PRETEXT IV), initial AFP level (≤1000 ng/mL in PRETEXT I-III, and ≤100 ng/mL in PRETEXT IV) [25–27]. The gene discussed is AFP; the disease is hepatoblastoma.