Delving further into lipid mediated signaling other than S1P, we noted a significant increase in gene expression of LPA receptor 3 in the WT HO (1.78 fold increase with FDR of 0.014869) which is in agreement with hyperoxia studies carried out in rat BPD models [50]. The gene discussed is MBTPS1; the disease is bronchopulmonary dysplasia.