While obesity appears to enhance FA transport and oxidation predominately in SSM by an increase of FAT/CD36, CS, and β-hydroxyacyl-CoA dehydrogenase activities with unaltered CPT1 [19], the absence of obesity and presence of T2DM lead to enhancement of FA oxidation only in IFM by CPT-I. Here, CS is linked to obesity due to melanocortin 4 receptor deficiency.