Carriers of the T allele were at higher risk for developing Pv-malaria (TLR5 OR = 2.1, [95% CI: 1.0–4.3, p = 0.034]; TLR9 OR = 1.3, [95% CI: 1.0–1.7, p = 0.02]). This evidence concerns the gene TLR5 and malaria.