Similarly, analysis of canonical pathways showed significant female bias in the up-regulation of immune-related processes (Fig 3) including the role of IL-17A in arthritis, granulocyte adhesion and diapedesis, and cytokine production; whereas, the top canonical pathways regulated by male-biased genes were hepatic fibrosis and hepatic stellate cell activation (Table 6). The gene discussed is IL17A; the disease is arthritic joint disease.