STAT3 and post-traumatic stress disorder: However, none of them, by RNA-Seq analysis, had all of the transcript variants dysregulated like STAT3. To that end, we checked the level of expression of STAT3 transcripts in our RNA-Seq data and observed that all the three variants of STAT3 were downregulated in the PBMCs of PTSD patients compared with healthy controls (Figure 3c).