AGO2 and post-traumatic stress disorder: In support of this, many of the miRNAs selected for analysis were also reduced in their abundance after in vitro knockdown of STAT3. Thus, in the light of the recent report by Wingo et al.,36 we believe that indeed DCR1 and AGO2 are downregulated in the PBMCs of PTSD patients, which possibly results from decreased STAT3 expression, and eventually culminate into a lowered miRNA expression.