DAGLB and Anxiety: DAGLB is known to be involved in the biosynthesis of 2-arachidonoyl-glycerol (2-AG), a key endogenous endocannabinoid in the endocannabinoid signalling system.47, 48 Interestingly, the role of the endocannabinoid system in anxiety and anxious behaviours is supported by a considerable body of research in both human and animal studies.49, 50, 51 In this study, we found an increase in DAGLB expression with greater treatment response.