In conclusion, the naturally selected AMPs, phylloseptin-PTa, identified from the skin secretion of P. tarsius, and phylloseptin-PHa, identified from the skin secretion of P. hypochondrialis, showed effective antimicrobial activities on the tested Gram-positive bacteria and the antibiotic-resistant bacteria MRSA, and displayed strong biofilm eradicative activity while inhibiting the proliferation of non-small cell lung cancer cells H157. The gene discussed is ADSL; the disease is non-small cell lung carcinoma.