To demonstrate the miRNA regulation of MICB protein expression in cancer cell lines, two models were designed: (i) HeLa, a cervical cancer cell line with high expression of MICB was transfected with mimic miRNAs to repress MICB expression; (ii) KKU-214, a cholangiocarcinoma cell line, with low MICB expression was transfected with anti-sense against endogenous miRNAs to knock down miRNAs leading to increased MICB expression. This evidence concerns the gene MICB and cervical carcinoma.