TLR4 and Sepsis: Song and colleagues determined that bis-N-norgliovictin (119) derived from a marine fungus S3-1-c inhibited TNF-α, IL-6, interferon-β, and MCP-1 production by LPS-stimulated RAW 264.7 macrophages and affecting Toll-like receptor 4 (TLR-4) signal transduction pathways, as well as LPS-induced septic shock in mice, thus suggesting bis-N-norgliovictin might result in a useful therapeutic candidate for “sepsis and other inflammatory diseases” [124].