NKP80, included in this family, exerts an autonomous control of NK cells against excessive inflammatory response causing self-NK cells mediated cytolysis [10,11,12]; (iii) natural cytotoxicity receptors (NCR) which include NKP30, NKP44 and NKP46 and interact with ligands overexpressed on tumor cells and viral infected cells; and (iv) signaling lymphocyte activating molecule (SLAM) family of receptors which include SLAMF1, 2B4, NTB-A, CD48, CD84, Ly9, and CRACC. Here, NCR2 is linked to neoplasm.