In addition to MiT family tRCC, alveolar soft part sarcoma, melanoma, clear cell sarcoma, angiomyolipoma, and perivascular epithelioid cell tumor (PEComa) highly express MiT family transcription factors as well as show common morphological, immunohistochemical, and molecular features, including TFE3 rearrangement; TFE3 gene fusions have been identified in PEComas of the kidney and soft tissue, including those demonstrating melanin pigments [20,21]. The gene discussed is TFE3; the disease is melanoma.