Xp11 tRCC with a PRCC-TFE3 fusion shows a smaller structure of nested or papillary cells with less abundant cytoplasm and less conspicuous nuclei when compared with Xp11 tRCC with an ASPSCR1-TFE3 fusion. The gene discussed is TFE3; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.