TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: Recent evidence shows that the immunohistochemical positivity for TFE3 or TFEB in the nuclei does not directly provide a diagnosis of Xp11 tRCC or t(6;11) RCC because these proteins can be overexpressed in nuclei by mechanisms other than genetic fusion.