Long-term administration of lithium to murine models of AD-like tauopathies reduces tau lesions primarily by enhancing their ubiquitylation (Nakashima et al., 2005), whereas synthesis of molecules that bring tau and E3 ubiquitin ligases together aims to enhance tau polyubiquitylation and degradation (Chu et al., 2016). This evidence concerns the gene MAPT and Alzheimer disease.