Furthermore, Otub1 was shown to contribute directly to tau pathology, since Otub1 expression in primary neurons leads to enhanced tau aggregation and increased levels of oligomeric tau forms (Wang et al., 2017), which might be important given that tau oligomers have emerged as the pathogenic species in tauopathies (Lasagna-Reeves et al., 2010). This evidence concerns the gene MAPT and tauopathy.