In human AD brains, aggregated tau is monomethylated at seven lysine residues found in the proline-rich region and the R1 and R2 repeats within the MBD, of which K180 and K267 appear to be more frequently methylated, in contrast to K290 that displays the lowest level of methylation (Thomas et al., 2012). The gene discussed is MAPT; the disease is Alzheimer disease.