Further studies demonstrated that AGEs may be involved in the tau-associated pathogenesis of AD via reactive oxygen intermediates by activating NF-kB-induced transcription, which leads to increased expression of the cytokine IL-6, and by enhancing the synthesis of the amyloid precursor protein, which, as a consequence, promotes the release of the Aβ peptides under stress conditions (Yan et al., 1995). Here, APP is linked to Alzheimer disease.