Indeed, CCL5 levels are greater in induced sputum from poorly controlled asthmatics than from controlled asthmatics (116, 117); subjects undergoing acute exacerbations have higher CCL11 levels in induced sputum and plasma samples than subjects with stable asthma or healthy controls (111, 118–120); and CCL24 and CCL26 expression in airway epithelial cells are associated with lower forced expiratory volume in 1 s (FEV1), more asthma exacerbations, and increased sputum eosinophil counts (92, 121). This evidence concerns the gene CCL5 and asthma.