Despite the independent roles of autophagy and inflammasome in regulating the ROS-PKCα-JNK-NF-κBp65 pathway through the lipid-raft-mediated clustering of ANXA2, we revisited the issue of whether rVvpM has the ability to regulate the autophagic process and inflammasome formation due to the fundamental parts of these processes play role in regulating the production of IL-1β during bacterial infection. This evidence concerns the gene MAPK8 and bacterial infectious disease.