BCL2L1 and non-small cell lung carcinoma: 67. Antiapoptotic Bcl-XL and MCL1 both bind to VDAC1 and VDAC3 isoforms to promote mitochondrial Ca2+ uptake and drive cell migration (77–80). Importantly, disrupting the Bcl-XL-VDAC and MCL1-VDAC interactions was found to inhibit migration of triple negative breast cancer cells (80) and non-small cell lung carcinoma cells, respectively (78).