The acquisition of mesenchymal markers caused by PTEN abrogation can be a consequence of increased onco-miR levels: in particular, the miR-130 family, highly expressed in bladder cancer, shuts down PTEN protein, with increase of migration and invasiveness, MMP9 production, AKT, and FAK phosphorylation (77). The gene discussed is PTEN; the disease is urinary bladder carcinoma.