PTK2 and breast carcinoma: As reported for breast cancer (57), the insulin growth factor receptor 1 (IGF1R)-driven migration and invasion are predominantly mediated by FAK activation; moreover, transforming growth factor β, a well-known cytokine involved in EMT induction, causes FAK activation, triggers delocalization of E-cadherin from the plasma membrane, and increases levels of mesenchymal markers (58).