Merlin negatively regulates some targets including Src-FAK complex (61), and its deficiency could represent a potential biomarker for the treatment with FAK inhibitors: specific FAK inhibition of Merlin-negative mesothelioma cancer cells causes a relevant reduction in cell viability, suggesting the potential benefit of this approach in NF2 negative mesothelioma cancer patients (62). This evidence concerns the gene PTK2 and mesothelioma.