Interestingly, previous work from our team showed that increased expression of FAK and its strong association with HSP90α/β in cellular nuclear complexes were fundamental features of MSCs in refractory anemia with excess blasts (RAEB; a high-risk subtype of MDS), which was correlated with a higher proliferation capacity and decreased hematopoiesis support (13). This evidence concerns the gene PTK2 and myelodysplastic syndrome.