In our study, EA stimulation at acupoints GV20 and ST36 was shown to serve as a therapeutic strategy for the attenuation of neurofunction deficits, reductions in the cerebral infarction area, and enhancement of the protein and mRNA expression of EPO, the EpoR, p-JAK2, JAK2, p-STAT3, and STAT3 in the model of CIRI. The gene discussed is STAT3; the disease is brain infarction.