CD274 and neoplasm: Immunization of mice with PD-L1 deficient dendritic cells pulsed with OVA peptide resulted in effector CD8+ T cells that secreted increased levels of IFN-γ and were better able to control B16-OVA tumor growth as compared to effector CD8+ T cells primed by dendritic cells with intact PD-L1 expression (40).