IFNB1 and pneumococcal infection: In order to further evaluate the role of IFN-β, IFN-γ, and IL-10 in the immunoregulatory effect of HK1505 and PG1505 during secondary pneumococcal infection we used blocking anti-IFN-β, anti-IFN-γ, and anti-IL-10R antibodies as described in the experimental protocol of Figure S2 in Supplementary Material.