It has been shown that the fatty acetyl-CoA synthetase VL3 (ACSVL3) is involved in glioblastoma genesis, while neurospheres of glioblastoma CSC have high level of ACSVL3 expression, associated with expression of several stemness markers, such as CD133, ALDH, Musashi-1, and Sox-2 (24). This evidence concerns the gene PROM1 and glioblastoma.