However, in the production of IFN-γ by TCD8+, we observed a decrease of production of PBS i.l. and MSC i.l. in comparison to PBS i.v. and no difference was observed when compared MSC i.v. against PBS i.l. and MSC i.l. Altogether, the production of IL-10 by T CD4+ and T CD8+ cells in the group treated with MSC by i.v. is probably the major mechanism associated to increase the susceptibility to infection. Here, CD4 is linked to infection.