ANXA6 and familial pancreatic carcinoma: Also, increased pancreatic cancer aggressiveness was shown to be dependent on tumor cell-mediated uptake of CAF-derived Annexin A6+ (ANXA6) EVs, and while depletion of ANXA6 in CAFs impaired pancreatic tumor and metastasis occurrence, injection of CAF-derived ANXA6+ EVs enhanced tumorigenesis (47).