However, some preclinical evidences show that targeting VEGF signaling pathway with exogenous angiogenesis inhibitors such as anti-VEGF monoclonal antibody bevacizumab and receptor tyrosine kinase inhibitors sunitinib and sorafenib elicit evasive resistance response and cause a more aggressive cancer phenotype (Ebos et al., 2009; Paez-Ribes et al., 2009). The gene discussed is NTRK1; the disease is cancer.