Chen et al. (2016) found that endostatin can also suppress osteoclast formation. Moreover, endostatin also reportedly increased the infiltration of NK cells and CD8+ T cells in tumor tissues (Coutinho et al., 2007; Rocha et al., 2010). Gene therapy of endostatin regulated the alternative activation of macrophages but not macrophage recruitment (Foguer et al., 2016; Guo et al., 2016). Here, COL18A1 is linked to neoplasm.