In summary, it is suggested that in case of COPD pathogenesis, caspase-9, caspase-8, caspase-3 play crucial role in apoptosis (Kidokoro et al., 1977; Perlmutter, 1996; Churg and Wright, 2005; Gogebakan et al., 2014). This evidence concerns the gene CASP8 and chronic obstructive pulmonary disease.