AFDN and Parkinson disease: Whether AF-6 plays a role in the nigrostriatal dopaminergic pathway that is relevant to PD is relatively unexplored, although a previous report demonstrated that rasagiline-mediated rescue of dopaminergic neurons in MPTP-treated parkinsonian mice involves the activation of a spectrum of Trk-related signaling components including AF-6 (Mandel et al., 2007).