JAG1 and Alzheimer disease: Furthermore, analysis of the CSF indicates that Jagged1 is present in different truncations and the bands above 130 KDa corresponding to the full length protein [HCTLs: 1 ± 0.25, AD: 0.24 ± 0.05; t(10) = 2.93, p = 0.01; n = 6 patients per condition] and that below 130 KDa corresponding to the soluble protein [HCTLs: 1 ± 0.27, AD: 0.21 ± 0.03; t(10) = 2.94, p = 0.02; n = 6 patients per condition] appear to be substantially reduced in 5 out of 6 AD patients examined as compared with healthy CTLs (Figures 1E,F).