Analysis of Jagged1 immunofluorescence intensity in CA field neurons, defined by the larger appearance of their neurons and their sterotypical orientation, reveals a significant reduction of Jagged1 [Healthy CTLs: 3293.62 ± 196.31, AD: 1969.28 ± 172.50; F(1, 279) = 25.69, p < 0.001; n = 122 neurons analyzed in CTL and n = 158 neurons in AD sections, n = 5 patients per condition; Figure 1D]. Here, JAG1 is linked to Alzheimer disease.