TP53 and Huntington disease: Along with our previous data showing decreased levels of p53 expression in YAC128 iPSCs and human juvenile HD iPSCs (Szlachcic et al., 2015), we found a similar decrease in p53 expression in NSCs originating from YAC128 iPSCs (−52 ± 7%, p = 0.0006) (Figures 6A,B).