For instance, using a mice model that shows stress vulnerability and depression-like symptoms, it was shown that GluA1 mRNA levels decrease and that GluA2 mRNAs levels rise in DH in comparison to resilient mice; variation accompanied by an increase in overall AMPAR binding, measured with radioligand autoradiography (Schmidt et al., 2010). The gene discussed is GRIA2; the disease is major depressive disorder.