APP and Cognitive impairment: GIRK currents recorded in hippocampal neurons of these animals, which overexpress GIRK channels due to an additional copy of the GIRK2 gene (in addition to the amyloid precursor protein gene), are significantly more sensitive to inhibitory input through GABAB receptors, which others have shown leads to an impairment of excitatory input and cognitive deficits (Harashima et al., 2006; Best et al., 2007).