CTLA4 and melanoma: Moreover, other agents that target the immune system are being actively investigated to improve the efficacy and reduce the toxicity of therapies to cure melanoma, such as the use of anticytotoxic T-lymphocyte-associated protein 4 (CTLA-4) antibodies (ipilimumab) and T cell immunoglobulin and mucin domain 3 (TIM3)/CD137 [8].