In patients with exacerbation of GOLD III, the sHLA-I-CD8 concentrations in the serum (958.4 ± 346.8 U/ml) and EBC (1583 ± 390.8 U/ml) were considerably higher than that in the group of patients COLD II in the same period of the disease (759.4 ± 279.1 U/ml and 1385 ± 220.8 U/ml, resp., p < 0.05). Here, CD8A is linked to chronic obstructive pulmonary disease.