At this time point, 20% of WT mice and 40% of Tlr7−/− mice had developed bronchopneumonia, characterized by alveolar necrosis, neutrophilic infiltrates, hemorrhage, exudates, edema, and bacterial colonies (Fig. 7A and B show representative lesions) (11, 38). The gene discussed is TLR7; the disease is bronchopneumonia.