Hydrogen peroxide stimulates phosphorylation of the Factor Nuclear kappa B-inhibitor of kappa B (NF-κB–IκB) complex, activating NF-κB and facilitating nuclear translocation and downstream movement of proinflammatory cytokines, such as Tumour Necrosis Factor-α (TNF-α), which are very important in the pathogenesis of periodontal disease [24]. The gene discussed is TNF; the disease is periodontal disorder.