Our recent study reveals that MMP‐2 overexpression is crucial for human BC invasion (Jin et al., 2015), whereas inhibition of MMP‐2 expression by the anti‐cancer agent isorhapontigenin (ISO) dramatically attenuated both BC invasion in vitro and highly invasive BC formation in vivo (Jiang et al., 2016) . This evidence concerns the gene MMP2 and cancer.