More interestingly, in our Kaplan-Meier and multivariate regression analyses, we found pFAK-Y397 overexpression, but not total FAK expression or combined total FAK/pFAK-Y397 co-expression, was significantly associated with worse OS and worse PMOS in osteosarcoma patients with metastases at diagnosis or developed metastases during treatment/follow-up. The gene discussed is PTK2; the disease is osteosarcoma.