Therefore, in our study, we aimed to compare total FAK and pFAK-Y397 expression with clinicopathologic characteristics and OS of patients with various histologic subtypes of osteosarcoma who presented with metastatic disease at diagnosis or developed metastases during treatment/follow-up, as well as in all patients group including patients without metastasis at diagnosis. This evidence concerns the gene PTK2 and metastatic neoplasm.