In the gastric cancer subset of a large, public database of transcriptomic data the gene signature described by (CACNA-1H*CACNA-1I)/CACNA-1G was associated with both OS and DFS/PFS, even in subgroups defined by tumour stage, HER-2 expression, type of adjuvant chemotherapy and Lauren histology. The gene discussed is ERBB2; the disease is gastric cancer.