In order to refine the role of the TTCC gene signature in gastric cancer, we also tested the prognostic value of our signature in subgroups defined by: Lauren histotypes (intestinal, diffuse), adjuvant treatment (surgery only, 5-fluorouracil-based adjuvant chemotherapy, other chemotherapy) and HER-2 status (positive, negative). This evidence concerns the gene ERBB2 and gastric cancer.