Caffeic acid reduces liver fibrosis due to its ability to suppress the activation of hepatic stellate cells by inhibiting oxidative stress through decrease of Keap1 expression, inhibition of Keap1 and Nrf2 binding, and thus activating Nrf2 and leading to increased expression of antioxidative signals [62,63,64]. Here, KEAP1 is linked to Hepatic fibrosis.