Chlorogenic acids administration, or treatment in animal studies, reduces liver fibrosis through decreased expression of collagen I and collagen III, as well as reducing the expression of inflammatory cytokines, TLR4, myeloid differentiation factor 88, inducible nitric oxide synthase and cyclooxygenase-2 and nuclear factor-κB activation [59,60,61]. This evidence concerns the gene NOS2 and Hepatic fibrosis.